Journal article
Islam I. Teiba, Y. Mazrou, A. Makhlouf, Y. Nehela, A. Mohamed, A. M. Abbas, Islam Mamdouh, Emad H. El-Bilawy
Biology, 2024
Biology, 2024
Semantic Scholar
DOI
PubMedCentral
PubMed
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APA
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Teiba, I. I., Mazrou, Y., Makhlouf, A., Nehela, Y., Mohamed, A., Abbas, A. M., … El-Bilawy, E. H. (2024). Antibacterial Potential of Honeybee Venom and Monascus purpureus Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria. Biology.
Chicago/Turabian
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Teiba, Islam I., Y. Mazrou, A. Makhlouf, Y. Nehela, A. Mohamed, A. M. Abbas, Islam Mamdouh, and Emad H. El-Bilawy. “Antibacterial Potential of Honeybee Venom and Monascus Purpureus Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria.” Biology (2024).
MLA
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Teiba, Islam I., et al. “Antibacterial Potential of Honeybee Venom and Monascus Purpureus Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria.” Biology, 2024.
BibTeX Click to copy
@article{islam2024a,
title = {Antibacterial Potential of Honeybee Venom and Monascus purpureus Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria},
year = {2024},
journal = {Biology},
author = {Teiba, Islam I. and Mazrou, Y. and Makhlouf, A. and Nehela, Y. and Mohamed, A. and Abbas, A. M. and Mamdouh, Islam and El-Bilawy, Emad H.}
}
Abstract
Simple Summary This study explores and develops eco-friendly alternatives for multidrug-resistant bacterial pathogens. Herein, the potential antibacterial activity of honeybee venom (BV) and Monascus purpureus red dye (RD) extracts was investigated. Both BV and RD extracts inhibited the bacterial growth of E. coli, S. aureus, and E. faecalis in a dose-dependent manner while being more effective against S. aureus (MIC = 3.18 and 6.315 µg·mL−1, respectively). It is worth mentioning that the highest concentration (200 μg·mL−1) of both extracts was more effective than several standard antibiotics, particularly RD, which produced a significant inhibition zone (~20 mm) against S. aureus. SEM-based microscopy showed that both extracts disrupt bacterial cell membranes, indicating their ability to penetrate and damage bacterial cell walls. Moreover, GC-MS-based analysis showed high diversity in BV’s chemical composition and bioactive compounds (42 metabolites) and RD (23 metabolites), including polycyclic systems, fatty acids, and esters. Collectively, these findings suggest that BV and RD have strong antibacterial properties and potential applications as alternatives to conventional antibiotics. However, supplementary investigations are required to better understand these extracts’ physio-biochemical and molecular mechanisms within treated bacterial cells.