Metal Complexation of Bis-Chalcone Derivatives Enhances Their Efficacy against Fusarium Wilt Disease, Caused by Fusarium equiseti, via Induction of Antioxidant Defense Machinery

Journal article

Asmaa El-Nagar, A. Elzaawely, T. Xuan, M. Gaber, Nadia El‐Wakeil, Y. El‐Sayed, Y. Nehela
Plants, 2022

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
El-Nagar, A., Elzaawely, A., Xuan, T., Gaber, M., El‐Wakeil, N., El‐Sayed, Y., & Nehela, Y. (2022). Metal Complexation of Bis-Chalcone Derivatives Enhances Their Efficacy against Fusarium Wilt Disease, Caused by Fusarium equiseti, via Induction of Antioxidant Defense Machinery. Plants.

Chicago/Turabian Click to copy
El-Nagar, Asmaa, A. Elzaawely, T. Xuan, M. Gaber, Nadia El‐Wakeil, Y. El‐Sayed, and Y. Nehela. “Metal Complexation of Bis-Chalcone Derivatives Enhances Their Efficacy against Fusarium Wilt Disease, Caused by Fusarium Equiseti, via Induction of Antioxidant Defense Machinery.” Plants (2022).

MLA Click to copy
El-Nagar, Asmaa, et al. “Metal Complexation of Bis-Chalcone Derivatives Enhances Their Efficacy against Fusarium Wilt Disease, Caused by Fusarium Equiseti, via Induction of Antioxidant Defense Machinery.” Plants, 2022.

BibTeX Click to copy

@article{asmaa2022a,
  title = {Metal Complexation of Bis-Chalcone Derivatives Enhances Their Efficacy against Fusarium Wilt Disease, Caused by Fusarium equiseti, via Induction of Antioxidant Defense Machinery},
  year = {2022},
  journal = {Plants},
  author = {El-Nagar, Asmaa and Elzaawely, A. and Xuan, T. and Gaber, M. and El‐Wakeil, Nadia and El‐Sayed, Y. and Nehela, Y.}
}

Abstract

Sweet pepper (Capsicum annuum L.) is one of the most widely produced vegetable plants in the world. Fusarium wilt of pepper is one of the most dangerous soil-borne fungal diseases worldwide. Herein, we investigated the antifungal activities and the potential application of two chalcone derivatives against the phytopathogenic fungus, Fusarium equiseti, the causal agent of Fusarium wilt disease in vitro and in vivo. The tested compounds included 3-(4-dimethyl amino-phenyl)-1-{6-[3-(4 dimethyl amino-phenyl)-a cryloyl]-pyridin-2-yl}-propanone (DMAPAPP) and its metal complex with ruthenium III (Ru-DMAPAPP). Both compounds had potent fungistatic activity against F. equiseti and considerably decreased disease progression. The tested compounds enhanced the vegetative growth of pepper plants, indicating there was no phytotoxicity on pepper plants in greenhouse conditions. DMAPAPP and Ru-DMAPAPP also activated antioxidant defense mechanisms that are enzymatic, including peroxidase, polyphenole oxidase, and catalase, and non-enzymatic, such as total soluble phenolics and total soluble flavonoids. DMAPAPP and Ru-DMAPAPP also promoted the overexpression of CaCu-SOD and CaAPX genes. However, CaGR and CaMDHAR were downregulated. These results demonstrate how DMAPAPP and Ru-DMAPAPP could be employed as a long-term alternative control approach for Fusarium wilt disease as well as the physiological and biochemical mechanisms that protect plants.